US Patent No: 5,656,481

Number of patents in Portfolio can not be more than 2000

Compositions and methods for the delivery of biologically active molecules using cells contained in biocompatible capsules

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Abstract

This invention provides improved devices and methods for long-term, stable expression of a biologically active molecule using a biocompatible capsule containing genetically engineered cells for the effective delivery of biologically active molecules to effect or enhance a biological function within a mammalian host. The novel capsules of this invention are biocompatible and are easily retrievable. This invention specifically provides improved methods and compositions which utilize cells transfected with recombinant DNA molecules comprising DNA sequences coding for biologically active molecules operatively linked to promoters that are not subject to down regulation in vivo upon implantation into a mammalian host. Furthermore, the methods of this invention allow for the long-term, stable and efficacious delivery of biologically active molecules from living cells to specific sites within a given mammal. In addition, this invention provides a general means for maintaining, for extended periods of time, the in vivo expression of transgenes.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
NEUROTECH USA, INC.91000 EVRY49

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Baetge, Edward E Barrington, RI 9 203
Emerich, Dwaine F Providence, RI 31 687
Gentile, Frank T Warwick, RI 30 711
Hammang, Joseph P Barrington, RI 35 1024
Lindner, Mark D Bristol, RI 6 196
Winn, Shelley R Providence, RI 20 889

Cited Art

Patent Info (Count) # Cites Year
 
CONNAUGHT LABORATORIES LIMITED (3)
4,789,550 Microcapsule composition suitable for cardiovascular injection 87 1984
4,689,293 Microencapsulation of living tissue and cells 100 1984
4,806,355 Microencapsulation of living tissue and cells 104 1987
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (2)
4,749,620 Encapsulated active material system 78 1985
4,883,666 Controlled drug delivery system for treatment of neural disorders 161 1987
 
NEUROTECH S.A. (2)
4,892,538 In vivo delivery of neurotransmitters by implanted, encapsulated cells 253 1987
5,106,627 Neurological therapy devices 141 1990
 
REPLIGEN CORPORATION (2)
4,352,883 Encapsulation of biological material 406 1979
4,409,331 Preparation of substances with encapsulated cells 128 1982
 
CALIFORNIA INSTITUTE OF TECHNOLOGY (1)
5,049,493 Enhancement of cell growth by expression of a cloned hemoglobin gene 37 1989
 
CIRCE ACQUISITION CORP. (1)
5,002,661 Artificial pancreatic perfusion device 73 1989
 
CYTOTHERAPEUTICS, INC. (1)
4,753,635 Inducing analgesia by implantation of cells releasing neuroactive substances 40 1986
 
MERCK & CO., INC. (1)
4,686,098 Encapsulated mouse cells transformed with avian retrovirus-bovine growth hormone DNA, and a method of administering BGH in vivo 72 1984
 
MICRON TECHNOLOGY, INC. (1)
5,167,762 Anisotropic etch method 19 1991
 
NATIONAL PATENT DEVELOPMENT CORPORATION (1)
4,298,002 Porous hydrophilic materials, chambers therefrom, and devices comprising such chambers and biologically active tissue and methods of preparation 105 1979
 
PHILLIPS PETROLEUM COMPANY (1)
4,470,461 Organic nitro compounds as cosurfactants in enhanced oil recovery processes 6 1982
 
QUEEN'S UNIVERSITY AT KINGSTON, KINGSTON, ONTARIO, CANADA K7L 3N6 A NON-PROFIT EDUCATIONAL CORPORATION (1)
4,942,129 Multiple membrane microencapsulation 33 1988
 
SOMATIX THERAPY CORPORATION (1)
4,902,295 Transplantable artificial tissue 97 1987
 
THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (1)
4,353,888 Encapsulation of live animal cells 242 1980
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1)
5,082,670 Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system 187 1988
 
THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (1)
5,084,350 Method for encapsulating biologically active material including cells 69 1990
 
THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW (1)
5,122,464 Method for dominant selection in eucaryotic cells 46 1990
 
UNIVERSITY OF MASSACHUSETTS (1)
5,026,365 Method and apparatus for therapeutically treating immunological disorders and disease states 43 1987
 
WASHINGTON UNIVERSITY (1)
4,868,121 Islet isolation process 55 1985

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
GENELUX CORPORATION (11)
6,713,293 Encapsulated cells containing an amplified expression vector as a drug delivery device 12 1999
8,137,904 Light emitting microorganisms and cells for diagnosis and therapy of diseases associated with wounded or inflamed tissue 2 2003
7,588,767 Microorganisms for therapy 8 2004
7,588,771 Microorganisms for therapy 7 2005
7,662,398 Microorganisms for therapy 7 2006
8,021,662 Microorganisms for therapy 3 2007
7,763,420 Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders 3 2007
7,820,184 Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders 2 2008
8,323,959 Microorganisms for therapy 0 2008
7,754,221 Microorganisms for therapy 5 2009
8,221,769 Microorganisms for therapy 1 2009
 
CENTELION (3)
7,279,313 Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy 5 2002
7,364,894 Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy 5 2003
7,807,444 Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy 0 2006
 
DUKE UNIVERSITY (3)
6,303,355 Method of culturing, cryopreserving and encapsulating pancreatic islet cells 2 1999
6,365,385 Methods of culturing and encapsulating pancreatic islet cells 8 1999
6,783,964 Microencapsulated pancreatic islet cells 3 2002
 
NEUROTECH USA, INC. (3)
6,054,142 Biocompatible devices with foam scaffolds 12 1996
6,264,941 Compositions for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules 0 1999
6,231,879 Biocompatible devices with foam scaffolds 107 1999
 
FBP CORPORATION (2)
5,945,100 Tumor delivery vehicles 15 1996
6,461,641 Tumor delivery vehicles 2 1999
 
THE REGENTS OF THE UNIVERSITY OF MICHIGAN (2)
6,942,879 Bioartificial filtration device for filtering blood to mimic kidney function 7 2002
7,442,546 Method of modulating inflammatory response 7 2003
 
TITAN PHARMACEUTICALS, INC. (2)
6,210,664 Method for gene transfer to the central nervous system 2 1996
6,565,845 Method for gene transfer to the central nervous system 0 2000
 
VISION ET RECHERCHE (2)
6,267,954 Intraocular transplantation of encapsulated cells 8 1999
6,663,894 Intraocular transplantation of encapsulated cells 3 2001
 
ACCESS PHARMACEUTICALS, INC. (1)
6,521,431 Biodegradable cross-linkers having a polyacid connected to reactive groups for cross-linking polymer filaments 14 1999
 
GENENTECH, INC. (1)
6,277,820 Method of dopaminergic and serotonergic neuron formation from neuroprogenitor cells 10 1998
 
NEPHROS THERAPEUTICS (1)
7,332,330 Device for maintaining vascularization near an implant 3 2001
 
RESEARCH TRIANGLE INSTITUTE (1)
7,615,567 Compounds and methods for promoting smoking cessation 1 2005
 
RHONE-POULENC RORER S.A. (1)
6,977,174 Circular DNA molecule with conditional origin of replication, method for preparing the same and use thereof in gene therapy 5 1996
 
RUSH UNIVERSITY MEDICAL CENTER (1)
7,459,152 Erythropoietin administration to improve graft survival 0 2004