Compositions and methods for the delivery of biologically active molecules using cells contained in biocompatible capsules

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 5656481
SERIAL NO

08449946

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Abstract

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This invention provides improved devices and methods for long-term, stable expression of a biologically active molecule using a biocompatible capsule containing genetically engineered cells for the effective delivery of biologically active molecules to effect or enhance a biological function within a mammalian host. The novel capsules of this invention are biocompatible and are easily retrievable. This invention specifically provides improved methods and compositions which utilize cells transfected with recombinant DNA molecules comprising DNA sequences coding for biologically active molecules operatively linked to promoters that are not subject to down regulation in vivo upon implantation into a mammalian host. Furthermore, the methods of this invention allow for the long-term, stable and efficacious delivery of biologically active molecules from living cells to specific sites within a given mammal. In addition, this invention provides a general means for maintaining, for extended periods of time, the in vivo expression of transgenes.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
NEUROTECH USA, INC.91000 EVRY38

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Baetge, Edward E Barrington, RI 9 284
Emerich, Dwaine F Providence, RI 33 1249
Gentile, Frank T Warwick, RI 31 1256
Hammang, Joseph P Barrington, RI 36 1561
Lindner, Mark D Bristol, RI 6 274
Winn, Shelley R Smithfield, RI 21 1202

Cited Art Landscape

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* Cited By Examiner

Patent Citation Ranking

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UNIVERSITY OF MIAMI (3)
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CENTELION (7)
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