System for automated performance of the polymerase chain reaction

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United States of America Patent

PATENT NO 5656493
SERIAL NO

08199505

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Abstract

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There is disclosed herein a machine for performing nucleic acid amplification under computer control. The machine utilizes any one of a number of heating and cooling systems under control of a host computer which directs the heating and cooling systems to heat and cool a reaction-chamber-containing heat exchanger at appropriate times in the process. The reaction chambers are pre-loaded with the nucleic acid(s) to be amplified, a thermostable enzyme to catalyze polymerization, specific oligonucleotide primers, and four different nucleotide triphosphates. Also disclosed is the process for the amplification chain reaction implemented by the machine, which utilizes a thermostable enzyme.

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Patent Owner(s)

Patent OwnerAddress
APPLIED BIOSYSTEMS LLC850 LINCOLN CENTRE DRIVE FOSTER CITY CA 94404

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Johnson, Larry San Jose, CA 48 1475
Leath, Richard A Berkley, CA 3 659
Mezei, Louis M Madison, WI 10 808
Mullis, Kary B LaJolla, CA 32 12560
Wennberg, Timothy J Mariposa, CA 4 695
Widunas, Joseph T Freemont, CA 8 1399

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