Compounds which inhibit complement and/or suppress immune activity
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United States of America Patent
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Aug 12, 1997
Issued Date -
N/A
app pub date -
Nov 18, 1994
filing date -
Apr 15, 1988
priority date (Note) -
Expired
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Abstract
The present invention is directed to compounds which suppress immune responses and/or selectivly inhibit complement. These compounds contain an aromatic ring and are substituted dihydrobenzofurans, spirobenzofuran-2(3H)-cycloalkanes, and their open chain intermediates. The compounds of the present invention, and the phamaceutically acceptable salts thereof, interrupt the proteolytic processing of C5 to bioactive components, exhibit immunosuppressive activites, and have therapeutic utility in the amelioration of disease and disorders mediated by complement and/or immune activity.
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