Methods and compositions for high protein production from non-native DNA

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United States of America Patent

PATENT NO 5658763
SERIAL NO

08463675

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Abstract

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Disclosed herein are improved methods and compositions for achieving enhanced protein production expressed from non-native gene constructs, including single chain sFv and derivative sequences. The methods and compositions are particularly useful for creating stably transfected, contitutively expressing immortalized mammalian cell lines that exhibit high recombinant protein productivity while maintaining a low copy number per cell of the non-native recombinant DNA sequence encoding the protein of interest.

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Patent OwnerAddress
CREATIVE BIOMOLECULES INCHOPKINTON MASSACHUSETTS 01478

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dorai, Haimanti Lexington, MA 17 142
Oppermann, Hermann Medway, MA 112 3953

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