High affinity nucleic acid ligands containing modified nucleotides
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United States of America Patent
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Aug 26, 1997
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N/A
app pub date -
Apr 27, 1995
filing date -
Jun 11, 1990
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Abstract
Nucleic acid ligands containing modified nucleotides are described as are methods for producing such oligonucleotides. Such ligands enrich the chemical diversity of the candidate mixture for the SELEX process. Specific examples are provided of nucleic acids containing nucleotides modified at the 2'- and 5-position. Specific 2-OH and 2'-NH.sub.2 modified RNA ligands to thrombin are described.
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