Oligonucleotide dimers with amide linkages replacing phosphodiester linkages
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United States of America Patent
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Sep 2, 1997
Issued Date -
N/A
app pub date -
Dec 20, 1994
filing date -
Mar 31, 1993
priority date (Note) -
Expired
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Abstract
Disclosed are oligonucleotide analogs comprising oligonucleoside sequences having from 3 to about 200 bases and containing internucleoside linkages wherein amide linkages replace phosphodiester linkages that are the backbones of the natural oligonucleotides that make up RNA and DNA. Also disclosed are bifunctional nucleoside analogs, a process for preparing dimers and trimers therefrom, and a method of using these bifunctional nucleoside intermediates, including the dimers and trimers, to synthesize the above-described oligonucleotide analogs using conventional synthetic organic procedures known in the art, preferably in a solid phase synthesis, more preferably in an automated peptide synthesizer.
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