IL-12 inhibition of B1 cell activity
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United States of America Patent
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Sep 9, 1997
Grant Date -
N/A
app pub date -
Feb 2, 1995
filing date -
Feb 2, 1995
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention relates to a method of suppressing B1 cell activity in a host (e.g., mammalian, including human) comprising administering to the host an effective amount of IL-12 that significantly suppresses or inhibits B1 cell activity. In addition, the invention relates to a method of treating a B1 cell disorder in a host, comprising administering to the host an effective therapeutic amount of IL-12. The invention further encompasses a method of screening for substances (e.g., proteins, peptides, small molecules) which enhance or suppress the inhibition of B1 cell activity by IL-12. The invention also relates to a substance identified by the methods of screening for a substance which enhances or suppresses IL-12 inhibition of B1 cell activity.
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