US Patent No: 5,665,728

Number of patents in Portfolio can not be more than 2000

Method of treating hyperproliferative vascular disease

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Importance

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Abstract

This invention provides a method of preventing or treating hyperproliferative vascular disease in a mammal by administering an antiproliferative effective amount of rapamycin alone or in combination with mycophenolic acid.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
WYETHMADISON, NJ2039

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gregory, Clare Robert Menlo Park, CA 2 148
Morris, Randall Ellis Los Altos, CA 2 148

Cited Art

Patent Info (Count) # Cites Year
 
WYETH (6)
5,078,999 Method of treating systemic lupus erythematosus 116 1991
5,080,899 Method of treating pulmonary inflammation 119 1991
5,288,711 Method of treating hyperproliferative vascular disease 138 1992
5,256,790 27-hydroxyrapamycin and derivatives thereof 28 1993
5,252,579 Macrocyclic immunomodulators 75 1993
5,516,781 Method of treating restenosis with rapamycin 159 1994
 
HITACHI, LTD. (1)
2005/0186,696 Gas flowmeter and manufacturing method thereof 2005
 
WYETH-AYERST CANADA INC. (1)
4,885,171 Use of rapamycin in treatment of certain tumors 156 1984
 
OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (1)
5,100,899 Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof 158 1989

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
ABBOTT LABORATORIES (13)
7,455,853 Medical devices containing rapamycin analogs 1 2002
7,399,480 Methods of administering tetrazole-containing rapamycin analogs with other therapeutic substances using medical devices 3 2004
8,057,813 Multiple drug delivery from a balloon and a prosthesis 0 2005
8,257,724 Delivery of highly lipophilic agents via medical devices 0 2006
8,257,725 Delivery of highly lipophilic agents via medical devices 0 2006
8,257,726 Compositions, systems, kits, and methods of administering rapamycin analogs with paclitaxel using medical devices 0 2006
7,378,105 Drug delivery systems, kits, and methods for administering zotarolimus and paclitaxel to blood vessel lumens 8 2006
7,357,942 Compositions, systems, and kits for administering zotarolimus and paclitaxel to blood vessel lumens 6 2006
8,394,398 Methods of administering rapamycin analogs with anti-inflammatories using medical devices 0 2006
8,057,816 Compositions and methods of administering paclitaxel with other drugs using medical devices 0 2006
8,318,190 Method of treating disorders using compositions comprising zotarolimus and paclitaxel 0 2008
8,153,150 Methods of administering tetrazole-containing rapamycin analogs with other therapeutic substances for treatment of vascular disorder 0 2008
8,431,145 Multiple drug delivery from a balloon and a prosthesis 0 2009
 
BOSTON SCIENTIFIC SCIMED, INC. (12)
6,306,421 Therapeutic inhibitor of vascular smooth muscle cells 73 1997
6,358,989 Therapeutic inhibitor of vascular smooth muscle cells 45 1999
6,268,390 Therapeutic inhibitor of vascular smooth muscle cells 65 1999
6,491,938 Therapeutic inhibitor of vascular smooth muscle cells 69 2001
8,067,022 Therapeutic inhibitor of vascular smooth muscle cells 0 2001
6,599,928 Therapeutic inhibitor of vascular smooth muscle cells 44 2001
6,569,441 Therapeutic inhibitor of vascular smooth muscle cells 54 2001
6,663,881 Therapeutic inhibitor of vascular smooth muscle cells 49 2001
6,720,350 Therapeutic inhibitor of vascular smooth muscle cells 37 2002
7,625,410 Stent device and method 0 2006
8,158,670 Therapeutic inhibitor of vascular smooth muscle cells 0 2007
8,097,642 Therapeutic inhibitor of vascular smooth muscle cells 0 2007
 
WYETH (10)
8,029,561 Drug combination useful for prevention of restenosis 0 2000
6,776,796 Antiinflammatory drug and delivery device 89 2001
7,261,735 Local drug delivery devices and methods for maintaining the drug coatings thereon 45 2001
6,746,773 Coatings for medical devices 155 2001
8,303,609 Coated medical devices 0 2001
7,195,640 Coated medical devices for the treatment of vulnerable plaque 53 2002
7,108,701 Drug releasing anastomosis devices and methods for treating anastomotic sites 41 2002
7,056,550 Medical devices, drug coatings and methods for maintaining the drug coatings thereon 25 2003
7,300,662 Drug/drug delivery systems for the prevention and treatment of vascular disease 8 2004
8,236,048 Drug/drug delivery systems for the prevention and treatment of vascular disease 0 2004
 
AVANTEC VASCULAR CORPORATION (5)
7,018,405 Intravascular delivery of methylprednisolone 4 2001
6,471,980 Intravascular delivery of mycophenolic acid 114 2001
7,077,859 Apparatus and methods for variably controlled substance delivery from implanted prostheses 70 2001
7,083,642 Delivery of therapeutic capable agents 43 2002
6,858,221 Intravascular delivery of mycophenolic acid 5 2002
 
CORDIS CORPORATION (4)
7,223,286 Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent 14 2004
7,229,473 Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent 15 2006
7,217,286 Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent 8 2006
7,666,222 Methods and devices for delivering therapeutic agents to target vessels 4 2006
 
ICON INTERVENTIONAL SYSTEMS, INC. (4)
8,016,881 Sutures and surgical staples for anastamoses, wound closures, and surgical closures 1 2004
8,070,796 Thrombosis inhibiting graft 0 2005
7,967,855 Coated medical device 1 2005
8,114,152 Stent coating 0 2008
 
ICON MEDICAL CORP. (4)
7,211,108 Vascular grafts with amphiphilic block copolymer coatings 6 2004
7,488,444 Metal alloys for medical devices 1 2006
8,323,333 Fragile structure protective coating 0 2006
8,100,963 Biodegradable device 0 2006
 
480 BIOMEDICAL, INC. (2)
8,372,133 Polymeric implant delivery system 0 2009
8,137,396 Medical implant 0 2010
 
BIOTEGRA, INC. (2)
7,438,925 Drug eluting coatings for medical implants 0 2003
8,357,386 Drug eluting coatings for medical implants and methods of use 0 2005
 
CODMAN & SHURTLEFF, INC. (2)
7,195,648 Intravascular stent device 14 2003
6,960,228 Intravascular stent device 5 2003
 
VASCULAR THERAPIES, LLC (2)
6,726,923 Apparatus and methods for preventing or treating failure of hemodialysis vascular access and other vascular grafts 45 2002
7,807,191 Apparatus and methods for preventing or treating failure of hemodialysis vascular access and other vascular grafts 0 2004
 
AVANTAC VASCULAR CORPORATION (1)
6,939,375 Apparatus and methods for controlled substance delivery from implanted prostheses 6 2001
 
BRENNER, PAOLO (1)
8,435,520 Combinations of immunosuppressive agents for the treatment or prevention of graft rejections 0 2011
 
INNOVATIONAL HOLDINGS LLC (1)
7,517,362 Therapeutic agent delivery device with controlled therapeutic agent release rates 2 2004
 
ISOTECHNIKA INC. (1)
6,884,429 Medical devices incorporating deuterated rapamycin for controlled delivery thereof 48 2002
 
UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (1)
8,236,338 Adhesive composition for carrying therapeutic agents as delivery vehicle on coatings applied to vascular grafts 0 2005