Pharmaceutical spheroid formulation
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United States of America Patent
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-
Sep 23, 1997
Grant Date -
N/A
app pub date -
Apr 21, 1995
filing date -
Aug 12, 1991
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
A controlled release composition including spheroid cores of diltiazem or a pharmaceutically acceptable salt thereof and optionally a spheronizing agent, the cores being coated with a controlled release layer, and a method of manufacturing the same, is disclosed. The spheronizing agent when present is preferably microcrystalline cellulose. Ethylcellulose is a preferred release coating. The controlled release coating preferably contains a plasticizer, a surfactant and a tack-modifier.
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