US Patent No: 5,670,325

Number of patents in Portfolio can not be more than 2000

Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample

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Importance

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Abstract

Methods are provided for detecting the presence of mutant sequences in a subpopulation of gene sequences in a biological sample. These methods are particularly useful for identifying individuals with gene mutations indicative of early colorectal cancer.

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First Claim

Related Publications

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ESOTERIX GENETIC LABORATORIES, LLCBURLINGTON, NC55

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lapidus, Stanley N Bedford, NH 48 1106
Shuber, Anthony P Mendon, MA 100 1171
Ulmer, Kevin M Cohasset, MA 7 393

Cited Art

Patent Info (Count) # Cites Year
 
NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT (4)
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5,378,602 Highly informative microsatellite repeat polymorphic DNA markers twenty-[seven]six 47 1991
5,369,004 Five highly informative microsatellite repeat polymorphic DNA markers 47 1992
5,468,610 Three highly informative microsatellite repeat polymorphic DNA markers 56 1993
 
THE JOHNS HOPKINS UNIVERSITY (4)
5,380,645 Generalized method for assessment of colorectal carcinoma 48 1989
5,527,676 Detection of loss of the wild-type P53 gene and kits therefor 91 1993
5,492,808 Means for detecting familial colon cancer (FCC) 42 1993
5,532,108 Gene deleted in colorectal cancer of humans 36 1994
 
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (3)
5,087,617 Methods and compositions for treatment of cancer using oligonucleotides 170 1989
5,248,671 Methods and compositions for treatment of cancer using oligonucleotides 46 1991
5,489,508 Therapy and diagnosis of conditions related to telomere length and/or telomerase activity 119 1993
 
HITACHI, LTD. (2)
5,409,586 Method for analyzing nucleic acid or protein and apparatus therefor 32 1993
5,458,761 Method for analyzing nucleic acid or protein and apparatus therefor 55 1995
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (2)
4,535,058 Characterization of oncogenes and assays based thereon 72 1982
4,786,718 Method of preparing antibodies to characterize oncogenes 53 1985
 
ROCHE MOLECULAR SYSTEMS, INC. (2)
4,683,195 Process for amplifying, detecting, and/or-cloning nucleic acid sequences 2437 1986
5,468,613 Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids 72 1990
 
AMERICAN HEALTH FOUNDATION (1)
5,512,441 Quantative method for early detection of mutant alleles and diagnostic kits for carrying out the method 80 1994
 
BARNES INTERNATIONAL, INC. (1)
5,496,470 Magnetic separator 31 1994
 
BOARD OF RIJKS UNIVERSITTEIT LEIDEN THE, WASSENAARSEWEG 72 2333 AL, LEIDEN, THE NETHERLANDS, A PUBLIC BODY OF THE NETHERLANDS (1)
4,871,838 Probes and methods for detecting activated ras oncogenes 61 1985
 
CANCER INSTITUTE, JAPANESE FOUNDATION FOR CANCER RESEARCH (1)
5,352,775 APC gene and nucleic acid probes derived therefrom 54 1991
 
CANCER INSTITUTE, THE A CORPORATION OF JAPAN (1)
5,330,892 MCC gene (mutated in colorectal cancer) used for diagnosis of cancer in humans 48 1991
 
CARLSON, ERIC V. (1)
5,463,782 Foldable stool sample collection device 34 1994
 
DEKALB GENETICS CORPORATION (1)
5,508,164 Isolation of biological materials using magnetic particles 149 1993
 
E. I. DU PONT DE NEMOURS AND COMPANY (1)
5,126,239 Process for detecting polymorphisms on the basis of nucleotide differences 81 1990
 
FRED HUTCHINSON CANCER RESEARCH CENTER (1)
5,466,576 Modulation of PIF-1-type helicases 44 1993
 
HELENA LABORATORIES CORPORATION (1)
5,196,167 Fecal occult blood test product with positive and negative controls 43 1991
 
LIFECODES CORPORATION (1)
5,514,547 Molecular genetic identification using probes that recognize polymorphic loci 30 1994
 
MILES INC. (1)
5,348,855 Assay for nucleic acid sequences in an unpurified sample 132 1991
 
MONTEFIORE MEDICAL CENTER (1)
4,981,783 Method for detecting pathological conditions 180 1986
 
ONCOSELL, INC. (1)
4,857,300 Cytological and histological fixative formulation and methods for using same 45 1987
 
PHARMAGENICS, INC. (1)
5,362,623 Sequence specific DNA binding by p53 55 1992
 
PRINCETON UNIVERSITY (1)
5,382,510 Methods of diagnosing pre-cancer or cancer states using probes for detecting mutant p53 51 1992
 
SAIDI; FARROKH (1)
5,380,647 Simple test for detecting carcinoembryonic antigen in stool 29 1993
 
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (1)
4,333,734 Diagnostic device for fecal occult blood and method of use 56 1980
 
SYNGENTA LIMITED (1)
5,137,806 Methods and compositions for the detection of sequences in selected DNA molecules 76 1989
 
TYCO HEALTHCARE GROUP LP (1)
5,149,506 Stool collection and transport device 81 1991
 
V-TECH, INC. (1)
4,735,905 Specimen-gathering apparatus and method 40 1986
 
OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (5)
4,309,782 Device for collecting fecal specimens 51 1980
4,445,235 Stool specimen collector 38 1982
4,705,050 Moisture-activated floatation device 51 1985
4,982,615 Sterile container for collecting biological samples for purposes of analysis 35 1989
5,331,973 Method for obtaining stool samples for gastrointestinal cancer testing 31 1993

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
ESOTERIX GENETIC LABORATORIES, LLC (17)
6,146,828 Methods for detecting differences in RNA expression levels and uses therefor 51 1998
6,280,947 Methods for detecting nucleotide insertion or deletion using primer extension 25 1999
6,919,174 Methods for disease detection 5 2000
6,964,846 Methods for detecting nucleic acids indicative of cancer 5 2000
6,849,403 Apparatus and method for drug screening 3 2000
6,503,718 Methods for detecting mutations using primer extension for detecting disease 15 2001
6,428,964 Method for alteration detection 20 2001
6,498,012 Methods for detecting mutations using primer extension for detecting disease 11 2001
6,475,738 Methods for detecting mutations using primer extension for detecting disease 41 2001
6,482,595 Methods for detecting mutations using primer extension 13 2001
6,750,020 Method for alteration detection 4 2001
6,818,404 Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples 5 2002
7,776,524 Methods for analysis of molecular events 1 2003
7,981,607 Method for detecting recombinant event 1 2005
7,811,757 Methods for disease detection 0 2006
8,409,829 Methods for analysis of molecular events 0 2010
8,389,220 Method for detecting a recombinant event 0 2011
 
GENOMIC HEALTH, INC. (5)
8,008,003 Gene expression profiling of EGFR positive cancer 0 2003
7,569,345 Gene expression markers for breast cancer prognosis 4 2004
8,034,565 Gene expression markers for breast cancer prognosis 0 2009
8,148,076 Gene expression profiling of EGFR positive cancer 0 2011
8,206,919 Gene expression markers for breast cancer prognosis 0 2011
 
NSABP FOUNDATION, INC. (5)
7,526,387 Expression profile algorithm and test for cancer prognosis 3 2004
7,930,104 Predicting response to chemotherapy using gene expression markers 0 2005
7,622,251 Molecular indicators of breast cancer prognosis and prediction of treatment response 1 2005
7,723,033 Prediction of likelihood of cancer recurrence 0 2006
7,939,261 Expression profile algorithm and test for cancer prognosis 0 2009
 
THE JOHNS HOPKINS UNIVERSITY (5)
6,177,251 Method for detection of target nucleic acid by analysis of stool 21 1999
6,440,706 Digital amplification 31 2000
6,753,147 Digital amplification 18 2001
7,824,889 Digital amplification 0 2007
7,915,015 Digital amplification 0 2009
 
EXACT SCIENCES CORPORATION (4)
6,268,136 Methods for stool sample preparation 20 1998
6,551,777 Methods for preserving DNA integrity 16 2000
6,911,308 Methods for detecting, grading or monitoring an H. pylori infection 0 2001
6,406,857 Methods for stool sample preparation 17 2001
 
VERINATA HEALTH, INC. (3)
8,372,584 Rare cell analysis using sample splitting and DNA tags 0 2007
8,137,912 Methods for the diagnosis of fetal abnormalities 2 2007
8,168,389 Fetal cell analysis using sample splitting 1 2008
 
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (2)
7,368,233 Methods of screening for lung neoplasm based on stool samples containing a nucleic acid marker indicative of a neoplasm 5 2000
7,981,612 Methods of screening for supracolonic neoplasms based on stool samples containing a nucleic acid marker indicative of a neoplasm 0 2008
 
UNIVERSITY OF DELAWARE (2)
7,468,244 Polymorphism detection and separation 0 2002
7,229,767 Genomics applications for modified OLIGO nucleotides 0 2003
 
AFFYMETRIX, INC. (1)
6,709,816 Identification of alleles 2 1999
 
GENOMIC HEALTH (1)
7,767,391 Use of intronic RNA to measure gene expression 8 2004
 
INSTITUTO NAZIONALE TUMORI (1)
7,871,769 Gene expression markers for predicting response to chemotherapy 0 2005
 
TRANSGENOMIC, INC. (1)
6,210,885 Modifying double stranded DNA to enhance separations by matched ion polynucleotide chromatography 15 1998