Reiterative method for screening combinatorial libraries
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United States of America Patent
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Sep 23, 1997
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N/A
app pub date -
Jun 7, 1995
filing date -
Apr 5, 1994
priority date (Note) -
Expired
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Abstract
Libraries of compounds such as nucleic acids or peptides are contacted with a target molecule and libraries that have at least one compound that bind with at least a minimum activity are determined by a reiterative process in which a change in the rate of recovery (elimination) of compounds that bind to the target indicates that the library contains such a compound. The procedure may also be used to determine indirectly the sequence of such compound by employing sublibraries, each of which have a known entity at a known position of the compound.
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