Anti-tumor agent assay using PKR
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United States of America Patent
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Sep 23, 1997
Grant Date -
N/A
app pub date -
Oct 25, 1993
filing date -
Sep 29, 1992
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A method of screening human tissue for the presence of neoplastic cells, by determining the activity of PKR, P58 of anti-P58 in test cells being screened, and identifying candidate neoplastic cells on the basis of subnormal PKR, P58, or anti-P58 activity. The activities may be determined directly by measuring protein kinase activity or its equivalent, or measured indirectly, by detecting functional mutations in the various proteins. Also disclosed are assay kits for carrying out the screening method.
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