Method of pretreating an animal with a corticosteroid prior to infusion of a perfluorochemical emulsion
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United States of America Patent
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Sep 23, 1997
Grant Date -
N/A
app pub date -
Apr 25, 1996
filing date -
Oct 28, 1994
priority date (Note) -
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Abstract
This invention is directed to a method of attenuating or preventing the adverse side-effects of a perfluorochemical (PFC) emulsion on the hemostatic system and serum chemistry of an animal. The method includes intravenously administering a corticosteroid to an animal prior to intravenous administration of a PFC emulsion, in an amount sufficient to improve the adverse effects of the PFC upon the hemostatic system and serum triglyceride/enzyme levels of the animal. After administration of the corticosteroid, the PFC emulsion is administered intravenously. Preferably, the corticosteroid is dexamethasone, and the PFC is perfluorodichlorooctane.
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