US Patent No: 5,672,491

Number of patents in Portfolio can not be more than 2000

Recombinant production of novel polyketides

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Abstract

Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn catalyze the production of a variety of polyketides.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
THE JOHN INNES INSTITUTENORWICH10
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITYPALO ALTO, CA2686

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ebert-Khosla, Suzanne Stanford, CA 10 397
Fu, Hong Union City, CA 29 416
Hopwood, David A Norwich, GB 14 454
Kao, Camilla Palo Alto, CA 16 381
Khosla, Chaitan Palo Alto, CA 129 995
McDaniel, Robert Palo Alto, CA 54 491

Cited Art

Patent Info (Count) # Cites Year
 
ELI LILLY AND COMPANY (1)
4,935,340 Method of isolating antibiotic biosynthetic genes 48 1985

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
DSM IP ASSETS B.V. (51)
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7,247,461 Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof 31 2002
7,214,853 Schizochytrium PKS genes 45 2002
7,211,418 PUFA polyketide synthase systems and uses thereof 51 2004
7,217,856 PUFA polyketide synthase systems and uses thereof 51 2004
7,259,295 PUFA polyketide synthase systems and uses thereof 45 2005
7,256,022 Pufa polyketide synthase systems and uses thereof 45 2005
7,256,023 PUFA polyketide synthase systems and uses thereof 46 2005
7,271,315 PUFA polyketide synthase systems and uses thereof 51 2006
7,642,074 PUFA polyketide synthase systems and uses thereof 1 2007
7,759,548 Polyunsaturated fatty acid production in heterologous organisms using PUFA polyketide synthase systems 2 2007
7,939,716 PUFA polyketide synthase systems and uses thereof 1 2007
7,906,706 PUFA polyketide synthase systems and uses thereof 1 2007
7,902,427 PUFA polyketide synthase systems and uses thereof 1 2007
7,803,620 Pufa polyketide synthase systems and uses thereof 1 2007
7,626,009 PUFA polyketide synthase systems and uses thereof 1 2007
7,601,522 PUFA polyketide synthase systems and uses thereof 2 2007
7,960,524 PUFA polyketide synthase systems and uses thereof 1 2007
7,842,796 PUFA polyketide synthase systems and uses thereof 1 2007
7,816,504 PUFA polyketide synthase systems and uses thereof 1 2007
7,608,703 PUFA polyketide synthase systems and uses thereof 2 2007
7,608,702 PUFA polyketide synthase systems and uses thereof 2 2007
8,003,772 Chimeric PUFA polyketide synthase systems and uses thereof 2 2007
7,897,844 PUFA polyketide synthase systems and uses thereof 1 2007
7,973,149 PUFA polyketide synthase systems and uses thereof 1 2007
7,919,320 PUFA polyketide synthase systems and uses thereof 1 2007
7,807,442 PUFA polyketide synthase systems and uses thereof 1 2007
7,605,245 PUFA polyketide synthase systems and uses thereof 2 2007
7,847,077 PUFA polyketide synthase systems and uses thereof 1 2007
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8,426,686 Polyunsaturated fatty acid production in heterologous organisms using PUFA polyketide synthase systems 0 2010
8,309,796 Chimeric PUFA polyketide synthase systems and uses thereof 0 2011
 
KOSAN BIOSCIENCES, INC. (43)
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6,177,262 Recombinant host cells for the production of polyketides 7 1998
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6,258,566 Production of polyketides in bacteria and yeast 4 1999
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6,451,768 Macrolide antiinfective agents 5 2000
6,395,710 Macrolide antiinfective agents 9 2000
6,410,301 Myxococcus host cells for the production of epothilones 35 2000
6,509,455 Recombinant narbonolide polyketide synthase 3 2000
6,524,841 Recombinant megalomicin biosynthetic genes and uses thereof 8 2000
6,627,427 Heterologous production of 15-methyl-6-deoxyerthronolide B 1 2000
6,670,168 Recombinant Streptomyces hygroscopicus host cells that produce 17-desmethylrapamycin 3 2000
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6,858,411 Recombinant methods and materials for producing epothilone and epothilone derivatives 3 2000
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6,562,795 Motilide compounds 18 2001
6,902,913 Recombinant narbonolide polyketide synthase 0 2001
6,660,862 Polyketide synthase enzymes and recombinant DNA constructs therefor 4 2001
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7,680,601 Design of polyketide synthase genes 0 2001
6,759,536 Polynucleotides encoding the fkbA gene of the FK-520 polyketide synthase gene cluster 1 2001
6,828,126 Methods for introducing hydroxyl or epoxide groups into polyketides using OleP 0 2001
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6,794,366 Macrolide antiinfective agents 2 2002
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7,067,286 Cystobacterineae host cells containing heterologous PKS genes for the synthesis of polykedtides 1 2002
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6,750,205 Motilide compounds 2 2003
7,189,549 Recombinant polynucleotides encoding pro-geldanamycin producing polyketide synthase and accessory proteins, and uses thereof 1 2003
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7,402,421 Recombinant methods and materials for producing epothilone and epothilone derivatives 3 2004
7,714,118 Polynucleotides encoding the fkbB gene of the FK-520 polyketide synthase gene cluster 0 2004
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THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (17)
6,022,731 Recombinant production of novel polyketides 30 1997
6,391,594 Modified modular PKS with retained scaffold 11 1997
6,558,942 Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold 5 1998
6,500,960 Method to produce novel polyketides 4 1999
6,221,641 Method for making polyketides 11 1999
6,753,173 Methods to mediate polyketide synthase module effectiveness 0 2000
6,939,691 E. coli and Streptomyces host cells that contain MatBC genes or E. coli host cells that contain pcc genes useful for enhanced polyketide production 3 2000
6,551,802 Methods for making polyketides 2 2000
6,461,838 Recombinant production of novel polyketides 2 2001
6,984,515 Macrolide analogs 0 2001
6,927,057 Macrolide analogs 0 2001
6,969,611 Methods to prepare cells comprising heterologous polyketide synthase expression systems 0 2001
7,001,748 Methods of making polyketides using hybrid polyketide synthases 0 2002
6,710,189 Method to produce novel polyketides 0 2002
7,101,684 Modified modular polyketide synthase 0 2004
7,312,048 Recombinant production of novel polyketides 0 2005
7,741,456 Polyketides and antibiotics produced by combinatorial techniques 0 2006
 
BIOTICA TECHNOLOGY LIMITED (9)
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6,271,255 Erythromycins and process for their preparation 39 1999
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7,011,959 Heterologous production of polyketides 1 2000
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NOVARTIS AG (8)
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ABBOTT LABORATORIES (3)
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ORTHO-MCNEIL PHARMACEUTICAL, INC. (3)
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DOW AGROSCIENCES LLC (2)
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JOHN INNES CENTRE (2)
5,962,290 Recombinant production of novel polyketides 51 1997
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THE REGENTS OF THE UNIVERSITY OF MICHIGAN (2)
7,566,558 Nucleic acids and polypeptides involved in the production of cryptophycin 0 2007
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KOSAM BIOSCIENCES, INC. (1)
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MARTEK BIOSCIENCES CORPORATION (1)
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SUPERMEDIA LLC (1)
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1)
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UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (1)
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