Cyclic prodrugs of peptides and peptide nucleic acids having improved metabolic stability and cell membrane permeability
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United States of America Patent
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Sep 30, 1997
Grant Date -
N/A
app pub date -
Apr 25, 1995
filing date -
Apr 25, 1995
priority date (Note) -
Expired
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Abstract
Provided are cyclic prodrugs of biologically active peptides and peptide nucleic acids exhibiting improved cell membrane permeability and enzymatic stability, containing 3-(2'-hydroxy-4',6'-dimethyl phenyl)-3,3-dimethyl propionic acid and its deriveatives and acyloxyalkoxy linkers. Also provided are pharmaceutical compositions containing effective amounts of these cyclic prodrugs in combination with pharmaceutically acceptable carriers, excipients, or diluents.
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