Gas-exchange method of making gas-filled microspheres
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United States of America Patent
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Oct 7, 1997
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app pub date -
Jun 7, 1995
filing date -
Jun 7, 1995
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Abstract
Ultrasonic imaging agents comprising an insoluble gas may be made by a new process of gas exchange. A solution is supersaturated with the insoluble gas and then contacted with a conventional air-filled microsphere suspension in order to effectuate a gas exchange process. The insoluble gas-containing microsphere exhibits increased pressure resistance and stability over microspheres in which the gas exchange was performed passively.
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