Episomal vector systems and related methods
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United States of America Patent
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Oct 7, 1997
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N/A
app pub date -
Dec 2, 1993
filing date -
Dec 2, 1992
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Expired
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Abstract
An episomal vector sytem and methods for use in gene therapy in humans and animals. The vector contains a papilloma virus origin of replication, a vector maintenance sequence, a first promoter transcriptionally linked to a therapeutic nucleic acid sequence, a second promoter transcriptionally linked to a papilloma virus E1 gene sequence, and a third promoter transcriptionally linked to a papilloma virus E2 gene sequence or an E1/E2 fusion gene. The vector is capable of episomal replication in human or animal cells.
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