Bioassay for thrombogenesis and rabbit model
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United States of America Patent
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Oct 7, 1997
Grant Date -
N/A
app pub date -
Sep 7, 1993
filing date -
Feb 11, 1992
priority date (Note) -
Expired
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Abstract
An in vivo assay for determining the potential thrombogenic activity of a test compound entails pre-treating an animal with both a hepatoxin and either a bacterial agent (whole bacteria or bacterial toxins, including endotoxins) or a bacterial agent-induced cytokine, which pre-treatment enhances sensitivity to thrombogenic substances. The sensitized animal can be used in identifying a thrombogenic substance even when it is a weak potentiator of thrombogenesis, and in detecting smaller amounts of a strong potentiator.
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