Enterically administered recombinant poxvirus vaccines
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United States of America Patent
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Oct 14, 1997
Grant Date -
N/A
app pub date -
Jun 7, 1995
filing date -
Oct 28, 1994
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
The subject invention pertains to a novel recombinant vaccinia virus vaccine for use in immunizing animals and humans against disease. The vaccine comprises a live vaccinia or replication deficient mutant vaccinia virus capable of expressing a single or multiple heterologous genes or gene fragments. In a preferred embodiment, the recombinant virus is contained in an orally-administered package that will only dissolve in the host animal's gut. The subject invention also pertains to a method of inducing a broad protective immune response through the oral administration of the recombinant vaccinia virus.
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