In vitro differentiation of CD34.sup.+ progenitor cells into T lymphocytes
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United States of America Patent
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Oct 14, 1997
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N/A
app pub date -
Apr 21, 1995
filing date -
Apr 21, 1995
priority date (Note) -
Expired
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Abstract
The invention involves a method for the in vitro T cell production. A monolayer of non-human primate thymic stromal cells are cocultured in vitro with primate hematopoietic T cell progenitor cells. This results in the differentiation and growth of mature T cells. The T cells may be isolated at any sequential stage of differentiation and further expanded by coculture with a mitogenic agent. The T cells also may be genetically altered at any stage of the process. The effect of agents on the growth and differentiation of T cells may be measured by comparing a coculture containing the agent with a control coculture and comparing the differentiation or growth of the T cells progenitor cells in the test culture with the control culture. Kits and novel populations of T cells are provided.
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