Methods of treatment using pharmaceutically active ceramide-related compositions

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United States of America Patent

PATENT NO 5677337
SERIAL NO

08547688

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Abstract

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This invention provides a compound having the formula R.sup.1 --Y.sup.1 --CHZ.sup.1 --CH(NY.sup.2 Y.sup.3)--CH.sub.2 --Z.sup.2, wherein: R.sup.1 is a straight-chained alkyl, alkenyl or alkynyl group having from 8 to 19 carbon atoms in the aliphatic chain; Y.sup.1 is --CH.dbd.CH--, --C.tbd.C--or --CH(OH)CH(OH)--; Z.sup.1 is OH or a conversion-inhibiting group; Z.sup.2 is a conversion-inhibiting group; Y.sup.2 is H, a phenyl group, an alkyl-substituted phenyl group having from 1 to about 6 carbons in the alkyl chain, or an alkyl chain having from 1 to 6 carbons; Y.sup.3 is H or a group having the formula --C(O)R.sup.2 or --S(O).sub.2 R.sup.2 ; R.sup.2 is a straight-chained alkyl, alkenyl or alkynyl group having from 1 to 23 carbon atoms in the chain; and when Z.sup.2 is an amino, R.sup.2 is an aliphatic chain having from 1 to 9 or from 19 to 23 carbon atoms in the aliphatic chain.

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Patent Owner(s)

Patent OwnerAddress
TRANSAVE INC11 DEER PARK DRIVE SUITE 117 MONMOUTH JUNCTION NJ 08852

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ahmad, Imran Plainsboro, NJ 68 541
Janoff, Andrew S Yardley, PA 68 2470
Mayhew, Eric Monmouth Junction, NJ 26 373
Wei, Yong Branchburg, NJ 59 342

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