US Patent No: 5,677,355

Number of patents in Portfolio can not be more than 2000

Continuous open-cell polymeric foams containing living cells

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Abstract

A polymeric foam with continuous, open-cell pores containing living cells suitable for medical applications and methods for preparing these foams. The microporous foams are of controlled pore size that may be utilized in a variety of applications. In general, the foams are characterized in that the pores are continuous and open-celled. In preparing the foams, an organic polymer is melted and combined with a selected solid crystalline fugitive compound, that melts above about 25.degree. C. and/or that sublimates at above about 25.degree. C. or can be extracted, to produce a substantially isotropic solution. The solution is cooled under controlled conditions to produce a foam precursor containing the solidified fugitive composition dispersed through a matrix of the organic polymer. Crystals of fugitive composition are then removed by solvent extraction and/or sublimation, or a like process to produce microcellular foams having a continuous, open-cell structure. After removing the fugitive composition, living cells capable of producing biologically active products are added to the pores to produce a foam containing living cells.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
POLY-MED, INC.ANDERSON, SC81
SMITH & NEPHEW, INC.MEMPHIS, TN549

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Roweton, Susan L Clemson, SC 7 162
Shalaby, Shalaby W Anderson, SC 225 2937

Cited Art

Patent Info (Count) # Cites Year
 
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NORSET, L.P. (1)
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TWIN RIVERS ENGINEERING (1)
5,098,621 Method of forming a foam substrate and micropackaged active ingredient particle composite 21 1989
 
OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (2)
5,071,704 Device for controlled release of vapors and scents 81 1990
5,130,342 Particle-filled microporous materials 38 1990

Patent Citation Ranking

Forward Cites

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