US Patent No: 5,677,355

Number of patents in Portfolio can not be more than 2000

Continuous open-cell polymeric foams containing living cells

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

A polymeric foam with continuous, open-cell pores containing living cells suitable for medical applications and methods for preparing these foams. The microporous foams are of controlled pore size that may be utilized in a variety of applications. In general, the foams are characterized in that the pores are continuous and open-celled. In preparing the foams, an organic polymer is melted and combined with a selected solid crystalline fugitive compound, that melts above about 25.degree. C. and/or that sublimates at above about 25.degree. C. or can be extracted, to produce a substantially isotropic solution. The solution is cooled under controlled conditions to produce a foam precursor containing the solidified fugitive composition dispersed through a matrix of the organic polymer. Crystals of fugitive composition are then removed by solvent extraction and/or sublimation, or a like process to produce microcellular foams having a continuous, open-cell structure. After removing the fugitive composition, living cells capable of producing biologically active products are added to the pores to produce a foam containing living cells.

Loading the Abstract Image... loading....

First Claim

See full text

all claims..

Related Publications

Loading Related Publications... loading....

Patent Owner(s)

Patent OwnerAddressTotal Patents
POLY-MED, INC.ANDERSON, SC95
SMITH & NEPHEW, INC.MEMPHIS, TN719

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Roweton, Susan L Clemson, SC 7 194
Shalaby, Shalaby W Anderson, SC 272 3626

Cited Art Landscape

Patent Info (Count) # Cites Year
 
ENTEGRIS, INC. (3)
4,902,456 Fluorocarbon membranes and process for making fluorocarbon membranes 27 1988
4,828,772 Microporous membranes of ultrahigh molecular weight polyethylene 31 1988
4,906,377 Fluorocarbon membranes and process for making fluorocarbon membranes 16 1989
 
NORSET, L.P. (1)
4,603,076 Hydrophilic foam 46 1985
 
Twin Rivers Engineering (1)
5,098,621 Method of forming a foam substrate and micropackaged active ingredient particle composite 23 1989
 
Other [Check patent profile for assignment information] (2)
5,071,704 Device for controlled release of vapors and scents 105 1990
5,130,342 Particle-filled microporous materials 47 1990

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
DEPUY SYNTHES PRODUCTS, LLC (16)
8,366,787 Hybrid biologic-synthetic bioabsorbable scaffolds 1 2002
8,337,537 Device from naturally occurring biologically derived materials 1 2002
8,092,529 Meniscus regeneration device 6 2002
8,025,896 Porous extracellular matrix scaffold and method 2 2002
8,012,205 Cartilage repair and regeneration device 2 2002
7,914,808 Hybrid biologic/synthetic porous extracellular matrix scaffolds 7 2002
7,361,195 Cartilage repair apparatus and method 27 2002
7,201,917 Porous delivery scaffold and method 29 2002
7,163,563 Unitary surgical device and method 53 2002
7,160,333 Reinforced small intestinal submucosa 50 2003
7,819,918 Implantable tissue repair device 3 2003
7,513,866 Intestine processing device and associated method 0 2004
7,569,233 Hybrid biologic-synthetic bioabsorbable scaffolds 3 2005
7,595,062 Joint resurfacing orthopaedic implant and associated method 3 2005
7,799,089 Reinforced small intestinal submucosa 3 2006
7,871,440 Unitary surgical device and method 3 2006
 
DEPUY MITEK, LLC (10)
6,852,330 Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration 82 2000
6,884,428 Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration 88 2002
7,824,701 Biocompatible scaffold for ligament or tendon repair 24 2003
7,316,822 Conformable tissue repair implant capable of injection delivery 48 2003
8,657,881 Meniscal repair scaffold 0 2004
8,691,259 Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration 0 2005
8,449,561 Graft fixation device combination 0 2007
8,637,066 Biocompatible scaffold for ligament or tendon repair 0 2010
8,641,775 Viable tissue repair implants and methods of use 0 2011
8,496,970 Conformable tissue repair implant capable of injection delivery 1 2012
 
DEPUY MITEK, INC. (8)
8,226,715 Scaffold for connective tissue repair 9 2003
8,137,686 Nonwoven tissue scaffold 10 2004
8,110,210 Nonwoven tissue scaffold 0 2004
8,016,867 Graft fixation device and method 1 2004
8,221,780 Nonwoven tissue scaffold 6 2006
8,105,621 Nonwoven tissue scaffold 0 2006
7,875,296 Conformable tissue repair implant capable of injection delivery 39 2007
8,137,702 Conformable tissue repair implant capable of injection delivery 21 2010
 
ETHICON ENDO-SURGERY, INC. (8)
6,355,699 Process for manufacturing biomedical foams 76 1999
6,333,029 Porous tissue scaffoldings for the repair of regeneration of tissue 150 1999
6,306,424 Foam composite for the repair or regeneration of tissue 169 1999
6,534,084 Porous tissue scaffoldings for the repair or regeneration of tissue 113 2000
6,365,149 Porous tissue scaffoldings for the repair or regeneration of tissue 88 2000
7,112,417 Foam composite for the repair or regeneration of tissue 24 2001
6,712,850 Porous tissue scaffolds for the repair and regeneration of dermal tissue 6 2001
8,187,326 Attachment of absorbable tissue scaffolds to fixation devices 3 2002
 
ETHICON, INC. (6)
6,423,252 Methods of making micropatterned foams 20 2000
6,743,232 Tissue scaffold anchor for cartilage repair 50 2001
6,575,986 Scaffold fixation device for use in articular cartilage repair 38 2001
6,626,950 Composite scaffold with post anchor for the repair and regeneration of tissue 128 2001
6,989,034 Attachment of absorbable tissue scaffolds to fixation devices 82 2002
7,901,461 Viable tissue repair implants and methods of use 32 2003
 
ADERANS RESEARCH INSTITUTE, INC. (3)
7,198,641 Scaffolds for tissue engineered hair 6 2001
7,597,885 Tissue engineered biomimetic hair follicle graft 0 2004
7,985,537 Methods for determining the hair follicle inductive properties of a composition 4 2007
 
BIOMERIX CORPORATION (3)
7,763,077 Repair of spinal annular defects and annulo-nucleoplasty regeneration 19 2003
7,803,395 Reticulated elastomeric matrices, their manufacture and use in implantable devices 5 2004
8,801,801 At least partially resorbable reticulated elastomeric matrix elements and methods of making same 0 2010
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (2)
6,471,993 Three-dimensional polymer matrices 84 2000
7,815,826 Manufacturing process, such as three-dimensional printing, including solvent vapor filming and the like 5 2005
 
1208211 ONTARIO LIMITED (1)
6,077,989 Resorbable implant biomaterial made of condensed calcium phosphate particles 159 1998
 
BONEARTIS AG (1)
8,814,936 Porous material for use as implant, bone replacement and in general as material 0 2005
 
CORPORATION DE L'ECOLE POLYTECHNIQUE DE MONTREAL (1)
8,007,823 Microporous articles comprising biodegradable medical polymers, method of preparation thereof and method of use thereof 1 2004
 
DEPUY PRODUCTS, INC. (1)
7,354,627 Method for organizing the assembly of collagen fibers and compositions formed therefrom 9 2004
 
EASTMAN KODAK COMPANY (1)
6,958,365 Manufacturing process for open celled microcellular foam 7 2003
 
KCI LICENSING, INC. (1)
8,702,711 Reduced pressure augmentation of microfracture procedures for cartilage repair 0 2009
 
KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (1)
6,946,143 Medical materials and porous scaffolds for tissue engineering made from the biodegradable glycolide/ε-caprolactone copolymer 9 2002
 
Medlden, LLC (1)
7,585,323 In vitro mechanical loading of musculoskeletal tissues 1 2001
 
PLINST GIKEN CO., LTD. (1)
6,391,233 Method of producing a porous product 3 2000
 
POLY-MED, INC. (1)
5,969,020 Microporous polymeric foams and microtextured surfaces 35 1998
 
PROXY BIOMEDICAL LIMITED (1)
8,796,015 Tissue scaffold 0 2005
 
THE REGENTS OF THE UNIVERSITY OF MICHIGAN (1)
7,575,759 Tissue engineering scaffolds 5 2002