Hemoglobins as drug delivery agents
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United States of America Patent
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Oct 21, 1997
Grant Date -
N/A
app pub date -
Jul 12, 1994
filing date -
Nov 8, 1991
priority date (Note) -
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Abstract
The invention relates to methods and compositions for delivering drugs to the body by binding them to hemoglobin. This technique stabilizes the drug and extends its half-life in the body. The drug may be chemically coupled to or adsorbed on the hemoglobin chain(s). Therapeutics are preferably linked to an artificial hemoglobin via a cysteine located deep within a cleft in the hemoglobin molecule.
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