Tetronic and thiotetronic acid derivatives as phospholipase A.sub.2 inhibitors
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United States of America Patent
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Oct 21, 1997
Grant Date -
N/A
app pub date -
May 15, 1995
filing date -
Apr 12, 1991
priority date (Note) -
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Abstract
There are disclosed compounds of the formula: ##STR1## wherein X is --CH.sub.2 R; Y is --O-- or --S--; R.sup.1 and R.sup.2 are each, independently, hydrogen or lower alkyl; or a pharmaceutically acceptable salt thereof; which by virtue of their ability to inhibit PLA.sub.2, are of use as antiinflammatory agents and there is also disclosed a method for the treatment of immunoinflammatory conditions, such as allergy, anaphylaxis, asthma and inflammation in mammals.
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