Method and apparatus for mimicking protein active sites

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United States of America Patent

PATENT NO 5680331
SERIAL NO

08290445

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Abstract

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A method for generating multiple mimics of an active site of a molecule, such as a protein, using computer modeling of the active site. A putative active site is identified, and the amino acids, or residues, purportedly responsible for the biological activity in question are located. These are represented as virtual residues in a model of the active site. The method generates many different possible representations of the active site of the selected protein, presenting the user with a choice of premodeled molecules for synthesis and testing as a substitute for the protein.

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Patent Owner(s)

Patent OwnerAddress
CHIRON CORPORATION4560 HORTON STREET R4608 EMERYVILLE CA 94608 UNITED STATES OF AMERICA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Blaney, Jeffrey M Oakland, CA 5 315
Siani, Michael A Oakland, CA 6 196

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