EGS-mediated inactivation of target RNA
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United States of America Patent
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Nov 4, 1997
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N/A
app pub date -
Jan 13, 1995
filing date -
Jan 13, 1995
priority date (Note) -
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Abstract
Modified external guide sequence (EGS) molecules that mediate cleavage of specific target RNAs have been constructed. The modified molecules are external guide sequence molecules for RNAse P which are designed to specifically bind to and promote RNAse P-mediated cleavage of target RNA molecules and to have enhanced nuclease resistance. Specific regions are modified to achieve enhanced stability while maintaining RNAse P activity. Modified external guide sequence molecules suitable for use in the treatment of hepatitis B viral infections have been constructed.
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