US Patent No: 5,683,899

Number of patents in Portfolio can not be more than 2000

Methods and compositions for combinatorial-based discovery of new multimeric molecules

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Abstract

The present invention prowdes methods and compositions for producing and screening combinatorial libraries of multimeric proteins. The present invention relies on the use of filamentous fungal heterokaryons that are produced using two or more parent strains into which a population of DNA molecules encoding variants of a multimeric protein have been introduced.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
UNIVERSITY OF HAWAIIHONOLULU, HI188

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Stuart, W Dorsey Kaneohe, HI 10 125

Cited Art

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DANISCO US INC. (1)
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ST. LOUIS UNIVERSITY, A NON-PROFIT ORG. (1)
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1)
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WASHINGTON UNIVERSITY (1)
5,177,193 Modified forms of reproductive hormones 21 1990
 
ZYMOGENETICS, INC. (1)
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Patent Citation Ranking

Forward Cites

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CODEXIS MAYFLOWER HOLDINGS, LLC (10)
6,326,204 Evolution of whole cells and organisms by recursive sequence recombination 15 1998
6,379,964 Evolution of whole cells and organisms by recursive sequence recombination 33 1999
6,251,674 Evolution of whole cells and organisms by recursive sequence recombination 17 2000
6,716,631 Evolution of whole cells and organisms by recursive sequence recombination 6 2000
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GLYCOFI, INC. (6)
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8,211,691 Methods for producing modified glycoproteins 0 2007
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JAPAN TOBACCO INC. (5)
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6,207,418 Production of a multimeric protein by cell fusion method 6 1999
6,420,140 Production of multimeric protein by cell fusion method 10 2001
6,677,138 Production of a multimeric protein by cell fusion method 1 2001
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PHIGENIX, INC. (3)
8,080,534 Targeting PAX2 for the treatment of breast cancer 1 2010
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5,968,361 Rapid method for separation of small molecules using reverse phase high performance liquid chromatography 13 1998
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DANISCO US INC. (1)
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INTREXON CORPORATION (1)
8,163,533 Methods and compositions for combinatorial-based production of multivalent recombinant antigens 0 2005
 
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7,629,170 Evolution of whole cells and organisms by recursive sequence recombination 2 2006
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1)
5,989,814 Screening methods in eucaryotic cells 15 1997
 
OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (2)
7,964,577 Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy 0 2006
8,318,692 Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy 0 2011