Method for determination of the amount of either phosphotyrosine or phosphoserine in a protein
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United States of America Patent
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Nov 11, 1997
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N/A
app pub date -
Jun 6, 1995
filing date -
Jun 6, 1995
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Expired
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Abstract
Traditional methods for measuring the phosphorylation state of cellular proteins have relied on .sup.32 P-orthophosphate labeling of cells in culture. The problems associated with radioactive isotopes have therefor prohibited phosphorylation studies on whole animals and humans. The present invention provides a unique technique that allows quantitative attachment of probes (e.g. fluorophors or biotin) to phospho-proteins and peptides by activating phospho-amino acids. the phosphorylation state of cellular proteins derived from human tissues can now be measured. This method can be used for early detection of cancer and diabetes and also for the identification of pharmaceutical agents.
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