Prevention of protein aggregation
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United States of America Patent
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Nov 18, 1997
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N/A
app pub date -
Dec 16, 1994
filing date -
Dec 16, 1994
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Abstract
A method of selecting anti-aggregation molecules with chaperone-like activity that have characteristics including binding to a native target molecule epitope with a high binding constant and are non-inhibitory to the biological activity of the target molecule. The method molecules denaturating a target molecule in the presence of presumptative antiaggregation molecules to prevent the target molecules from self-or induced-aggregation. The nonaggregated target molecule coupled to the anti-aggregation molecule is then tested for bioactivity.
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