Monoclonal antibodies against human colon carcinoma-associated antigens and uses therefor

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United States of America Patent

PATENT NO 5688657
SERIAL NO

08304524

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Abstract

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Monoclonal antibodies, in particular 33.28 and 31.1, and chimeric antibodies, in particular mouse/human chimeric Chi #1 specific for glycoprotein antigens of colon carcinoma-associated antigens which are immunogenic in humans, are disclosed. Such antibodies, and fragments and derivatives thereof, are useful in immunodiagnosis and immunotherapy of human colon, breast, and ovarian cancer, and for purification of antigens which can serve as immunotherapeutic agents. Methods of detecting the colon carcinoma-associated antigen in a sample, and methods for treating subjects having colon, breast, and ovarian carcinomas are disclosed.

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Patent Owner(s)

Patent OwnerAddress
NEOGENIX ONCOLOGY INC445 NORTHERN BOULEVARD GREAT NECK NY 11021

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Arlen, Myron Great Neck, NY 17 213
Tsang, Kwong Y Bethesda, MD 15 180

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