Self-modifying RNA molecules and methods of making

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United States of America Patent

PATENT NO 5688670
SERIAL NO

08299498

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Abstract

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The invention concerns a method for creating, identifying, and isolating ribozymes capable of binding a selected ligand and catalyzing a reaction involving the selected ligand. The method entails sequential selections for ligand binding molecules and catalytic molecules. The invention also includes novel ribozymes produced by these methods.

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Patent Owner(s)

Patent OwnerAddress
GENERAL HOSPITAL CORPORATION THE55 FRUIT STREET BOSTON MA 02114

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lorsch, Jon R Cambridge, MA 3 46
Szostak, Jack W Boston, MA 18 1381
Wilson, Charles Bonny Doon, CA 82 1076

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