Non-fibrogenic high mannuronate alginate coated transplants, processes for their manufacture, and methods for their use
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United States of America Patent
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Dec 2, 1997
Issued Date -
N/A
app pub date -
Sep 2, 1994
filing date -
May 29, 1992
priority date (Note) -
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Abstract
A transplant with a core of a viable, physiologically active, cell(s) and a non-fibrogenic coating of alkaline earth metal alginate having a high mannuronate to guluronate molar ratio and free from fibrogenic amounts of fucose, sulfate, phloroglucinol and protein moieties. The coating has a permeability sufficiently low and a thickness sufficiently large to protect the tissue cells from host immunological agents after transplantation, the coating also being sufficiently permeable and thin to permit the diffusion of cell sufficient nutrients and cell products through the coating required for cell viability. The alginate coating can be reacted with polylysine to form a polylysine-alginate complex on the outer surface thereof. The complex can then be reacted with polyaspartic acid to provide a physiologically acceptable negative surface charge.
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