Bioprosthetic heart valves having high calcification resistance
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United States of America Patent
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Dec 16, 1997
Grant Date -
N/A
app pub date -
Jun 7, 1995
filing date -
Jul 13, 1994
priority date (Note) -
Expired
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Abstract
The specification describes an invention of calcification resistant bioprosthetic heart valves which can be used for a long term, and have good blood compatibility and in vivo stability, and have high calcification resistance. The bioprosthetic heart valves of the invention can be prepared by binding sulfonated polyethylene oxide (PEO) derivatives covalently to the tissue. The valves have an anionic effect equal to that of chondroitin sulfate, space filling effect, and blocking effect of the carboxyl group of collagen which has been known as one factor of the calcium deposition,. In particular, the present method has better advantages in view of calcification resistance than any other conventional methods, because it suppresses thrombosis and embolism and decreases incidence of infection.
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