Tissue-engineered bone repair using cultured periosteal cells
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United States of America Patent
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Dec 23, 1997
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app pub date -
Oct 20, 1995
filing date -
Oct 20, 1995
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Abstract
Periosteal cells have been grown in cell culture and have been shown to have an osteoblastic phenotype, with production of osteocalcin and glycosaminoglycan. When seeded into polymeric implants, repair of critical size cranial defects was demonstrated and was confirmed by histology, biochemical assays, and radiodensitometry.
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