Methods of making transgenic animals producing oligosaccharides and glycoproteins
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United States of America Patent
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Dec 23, 1997
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app pub date -
May 2, 1995
filing date -
Mar 9, 1994
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Abstract
The invention relates to transgenic non-human mammals characterized in that the genome of said mammals contain at least one heterologous gene encoding for the production of heterologous catalytic entity selected from the group consisting of enzymes and antibodies, and wherein said catalytic entity produces a second heterologous product in the milk of said mammal. Especially useful in the practice of the invention are human glycosyltransferases and transgenic sheep, goats and cows. The heterologous product includes oligosaccharides and glycoconjugates.
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