Solid phase synthesis of oligonucleotides with stereospecific substituted phosphonate linkages by pentavalent grignard coupling
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United States of America Patent
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Dec 30, 1997
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N/A
app pub date -
Sep 2, 1994
filing date -
Sep 2, 1994
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Expired
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Abstract
The present invention provides a method for producing an oligonucleotide having stereospecific substituted phosphonate linkages by use of a pentavalent Grignard coupling reaction on a solid phase support. The method can be used for automated synthesis of oligonucleotides having sequential equatorial or axial stereospecific substituted phosphonate linkages.
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