Controlled release formulation for poorly soluble basic drugs
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United States of America Patent
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Jan 6, 1998
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N/A
app pub date -
Dec 19, 1995
filing date -
Dec 19, 1995
priority date (Note) -
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Abstract
A controlled release, oral, solid, pharmaceutical composition for a reduced daily dosage regimen is described where the therapeutic ingredient is a poorly soluble basic drug. The formulation comprises the use of a water-soluble alginate salt, a complex salt of alginic acid and an organic carboxylic acid in admixture with the therapeutic drug. A particular embodiment comprising a once a day dosage form for clarithromycin is also described.
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