Modified signal sequences
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United States of America Patent
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Jan 6, 1998
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N/A
app pub date -
Oct 13, 1992
filing date -
May 25, 1992
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Abstract
The present invention describes a method for reducing processing ambiguity of signal peptidases. Specifically, the C-terminus of a signal sequence is mutated in a such a manner that the secreted protein contains the correct N-terminal amino acid. Furthermore, the present invention provides an hIL-3 which is essentially homogenous at its N-terminus.
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