Methods of producing antigen forks
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United States of America Patent
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Jan 6, 1998
Grant Date -
N/A
app pub date -
Mar 1, 1995
filing date -
Apr 9, 1993
priority date (Note) -
Expired
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Abstract
The present invention relates to a class of molecules called 'antigen forks' that inhibit cell growth. These antigen forks possess separate binding elements for two different cell surface antigens and are believed to heterologously crosslink the antigens by binding to them. The two antigens recognized by an antigen fork differ in at least one cellular functional quality, but are simultaneously expressed on the surface of at least one cell type targeted for killing or growth inhibition. The present invention also relates to a method of assay to determine which antibodies may be useful in the preparation of antigen forks.
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