Importance

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Abstract

A prefilled syringe system is provided for two component pharmaceuticals, which is a combination of a first subassembly consisting of a capped bottomless pharmaceutical vial containing a first component and closed at its bottom end by a piston which can be connected to a plunger and a second subassembly consisting of a shell containing a second component and closed by a further piston and located in telescopable relationship with the plunger, a cap which can be forced onto the cap of the bottomless vial, and a double ended needle or a functionally equivalent cannula assembly which is caused to pierce both pistons as the assemblies are connected by forcing the cap onto the bottomless vial, thus placing the vials in communication. The shell vial is pressed towards the bottomless vial to express its contents into the latter, and the plunger and shell vial are then removed so that the cap and needle are left connected to the bottomless vial and the plunger may be connected to the piston of the bottomless vial to convert it into a syringe. The shell vial may telescope either over or within the plunger. In the first case, the plunger acts to operate the piston of the shell vial during expression of its contents, whereas in the latter case a separate component is required for this purpose.

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First Claim