Macrocyclic 13-membered ring derivatives of erythromycins A and B
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United States of America Patent
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Jan 27, 1998
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app pub date -
Jun 18, 1996
filing date -
Jun 18, 1996
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Abstract
Novel macrocyclic 13-membered ring-contracted compounds derived from erythromycins A and B having the Formula (I) ##STR1## and pharmaceutically acceptable salts thereof, wherein R, R.sup.1, R.sup.2, R.sup.3 and X are specifically defined, having use in treating gastrointestinal disorders associated with hypermotilinemia, pharmaceutical compositions thereof, a method of treating gastrointestinal disorders associated with hypermotilinemia with said pharmaceutical compositions, and processes for the preparation thereof.
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