Active agent transport systems
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United States of America Patent
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Feb 3, 1998
Grant Date -
N/A
app pub date -
Oct 25, 1994
filing date -
Jun 15, 1992
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Abstract
Methods for transporting a biologically active agent across a cellular membrane or a lipid bilayer. A first method includes the steps of: (a) providing a biologically active agent which can exist in a native conformational state, a denatured conformational state, and an intermediate conformational state which is reversible to the native state and which is conformationally between the native and denatured states; (b) exposing the biologically active agent to a complexing perturbant to reversibly transform the biologically active agent to the intermediate state and to form a transportable supramolecular complex; and (c) exposing the membrane or bilayer to the supramolecular complex, to transport the biologically active agent across the membrane or bilayer. The perturbant has a molecular weight between about 150 and about 600 daltons, and contains at least one hydrophilic moiety and at least one hydrophobic moiety. The supramolecular complex comprises the perturbant non-covalently bound or complexed with the biologically active agent. In the present invention, the biologically active agent does not form a microsphere after interacting with the perturbant. A method for preparing an orally administrable biologically active agent comprising steps (a) and (b) above is also provided as are oral delivery compositions. Additionally, mimetics and methods for preparing mimetics are contemplated.
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- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
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Patent Owner(s)
Patent Owner | Address | |
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NOVO NORDISK NORTH AMERICA OPERATIONS A/S | NOVO ALLÉ BAGSVAERD 2880 |
International Classification(s)
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
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Barantsevitch, Evgueni | New Rochelle, NY | 15 | 702 |
Leone-Bay, Andrea | Ridgefield, CT | 146 | 4462 |
Milstein, Sam J | Larchmont, NY | 59 | 3403 |
Santiago, Noemi B | Hawthorne, NY | 11 | 511 |
Sarubbi, Donald J | Bronxville, NY | 52 | 2264 |
Wang, Nai Fang | Long Island City, NY | 26 | 800 |
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Fee | Large entity fee | small entity fee | micro entity fee | due date |
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Fee | Large entity fee | small entity fee | micro entity fee |
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Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
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