Celiac antigen
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United States of America Patent
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Feb 10, 1998
Grant Date -
N/A
app pub date -
Mar 29, 1996
filing date -
Mar 29, 1996
priority date (Note) -
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Abstract
In this invention a novel antigen is provided for screening patients suspected of having celiac disease. The antigen is prepared by starting with human placenta tissue which is perfused with a herpes and collagenase buffer to obtain a signle cell suspension. This suspension is enriched to obtain an enriched protein portion and then separated out to obtain an embryonic celiac antigen (ECA). This ECA is used with serum from patients to effect binding of ECA with IgA in the serum while applying a human IgA antibody to the serum. The results are then read on a spectrophotometer to confirm or negate the presence of celiac disease.
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