Integrated nucleic acid analysis system for MALDI-TOF MS

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United States of America Patent

PATENT NO 5716825
SERIAL NO

08551501

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Abstract

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An integrated nucleic acid sample analysis system for matrix-assisted laser-desorption/ionization time-of-flight mass spectroscopy (MALDI-TOF MS) is described. The integrated system comprises a miniaturized sample preparation compartment interfaced directly with a MALDI-TOF ionization surface for amplifying and/or otherwise chemically manipulating an oligonucleotide analyte and presenting the analyte to a MALDI ionization surface for mass spectrometry analysis. The miniaturized integrated sample handling system disclosed herein finds application in the amplification and analysis of DNA samples for genetic diagnosis and other uses.

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Patent Owner(s)

Patent OwnerAddress
AGILENT TECHNOLOGIES INC5301 STEVENS CREEK BOULEVARD MS 1A-PB SANTA CLARA CA 95051-7201

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Apffel, James A Palo Alto, CA 7 836
Chakel, John A San Mateo, CA 3 690
Hancock, William S Hillsborough, CA 17 1141
Lichtenwalter, Kay San Jose, CA 12 1164

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