Crystalline trimetrexate salts and the process for making the same
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United States of America Patent
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Feb 10, 1998
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app pub date -
Jan 13, 1995
filing date -
Jan 13, 1995
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Abstract
The present invention provides for a crystalline form of trimetrexate either as a glucuronate, acetate, hydrochloride, methanosulfonate or lactate salt, which can be processed galenically as a stable, well-defined solid substance and processes for producing the crystalline forms. Such crystalline forms allow for prolonged stability in storage and for oral and intravenous administration of the drug.
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