Method of attaching heparin to, and immobilizing it on, inorganic substrate surfaces of cardiovascular implants
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United States of America Patent
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Feb 17, 1998
Grant Date -
N/A
app pub date -
Sep 11, 1996
filing date -
Sep 12, 1995
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A method of attaching heparin to, and immobilizing it on, inorganic substrate surfaces of cardiovascular implants such as cardiac valves or alloplastic vessel wall supports, comprising the following steps: activation of the inorganic substrate surface by etching, attachment, by exposure to ultraviolet light, of a photoactive benzophenone compound with an amino protective group as a spacer to the activated substrate surface, splitting off of the amino protective group by the aid of a non-aqueous piperidine solution, and covalent peptide-bonding of heparin to the free and reactive amino groups of the substrate surface by an aqueous heparin solution acting on the amino groups.
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