Peptide nucleic acids having amino acid side chains
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United States of America Patent
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Feb 17, 1998
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app pub date -
Jul 24, 1996
filing date -
Nov 22, 1993
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Abstract
A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than the corresponding DNA or RNA strands, and exhibit increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone, and contain alkylamine side chains.
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