Pseudopeptide lactam inhibitors of peptide binding to MHC class II proteins
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United States of America Patent
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Feb 17, 1998
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N/A
app pub date -
Oct 28, 1996
filing date -
Oct 30, 1995
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Expired
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Abstract
Compounds of the formula ##STR1## are inhibitors of peptide binding to major histocompatibility complex type II proteins and are useful in the treatment and prevention of autoimmune diseases including: rheumatoid arthritis, Type I diabetes, multiple sclerosis, lupus erythematosis, Graves disease and pemphigus. The present invention also provides novel compositions, methods of treatment employing the compounds of the present invention and methods of manufacture of the compounds of structural formula (I).
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