Position-addressable polynucleotide arrays
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United States of America Patent
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Mar 3, 1998
Grant Date -
N/A
app pub date -
Aug 29, 1995
filing date -
Aug 29, 1995
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A method for producing a high-density, position-addressable gene array is disclosed. The method includes contacting an array of different-sequence oligonucleotides having a unique, known combinatorial sequence associated with each position in the array with a set of extended gene probe templates which are complementary to the oligonucleotides at one of the template end regions. After hybridization, the oligonucleotides in the array are extended by strand-directed polymerization to form the probe array. Also disclosed is a probe array device formed by the method.
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