Pharmaceutical excipient having improved compressibility
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United States of America Patent
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Mar 10, 1998
Grant Date -
N/A
app pub date -
Jun 7, 1995
filing date -
Jan 9, 1995
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and an effective amount of a surfactant, which, in preferred embodiments is an anionic surfactant present in amounts ranging from about 0.1% to about 0.5%, by weight of the microcrystalline cellulose, wherein the microcrystalline cellulose and surfactant are in intimate association with each other. One preferred anionic surfactant utilized in the novel excipient is sodium lauryl sulfate.
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